Transcapillary Escape Rate of Albumin and Plasma Volume in Essential Hypertension

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Abstract
The transcapillary escape rate of albumin, the fraction of intravascular mass of albumin that passes to the extravascular space per unit time, was determined from the disappearance of intravenously injected 131I-labeled human serum albumin during the first 60 minutes after the injection in 10 normotensive and 18 hypertensive male subjects. The investigation was preceded by at least 12 hours of fasting and 30 minutes of rest in the supine position. The transcapillary escape rate of albumin was significantly increased in the hypertensive group: it averaged 7.6±1.2 (SD) %/hour compared with 5.6±1.1%/hour in the normotensive group (PPPP<0.05).