Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells
- 15 February 1984
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 218 (1) , 81-86
- https://doi.org/10.1042/bj2180081
Abstract
Denatured or modified proteins (including albumin and low-density lipoprotein) are catabolized in vitro via scavenger receptors. The distribution of formaldehyde-denatured albumin was studied in rat liver cells after i.v. injection of tracer doses of the protein. At 12 min after injection, most of the formaldehyde-denatured albumin (.apprx. 70% of the injected dose) was recovered in liver endothelial cells. Furthermore, isolated liver endothelial cells in suspension and in surface culture took up formaldehyde-denatured albumin by receptor-mediated endocytosis. The scavenger receptor in liver is mainly located on the endothelial cells. Implications for the catabolism of low-density lipoproteins are discussed.This publication has 19 references indexed in Scilit:
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