HLA as a marker of the hemochromatosis gene in Sweden
Open Access
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 68 (1) , 62-66
- https://doi.org/10.1007/bf00293874
Abstract
The frequency of HLA-A3 and HLA-B14 antigens was found to be significantly (P=<0.0001) higher in a series of 50 unrelated and unselected Swedish patients with idiopathic hemochromatosis (IH) than in controls, being 66% and 32% for A3 and 22% and 2% for B14. The haplotype A3B14 was associated with the highest risk in this material (relative risk 23.4). One family with this haplotype was traced back to the end of the seventeenth century. The pattern of HLA antigens associated with IH in Sweden shows remarkable similarity to those reported from England and Brittany.Keywords
This publication has 38 references indexed in Scilit:
- Idiopathic haemochromatosis in the Australian population: HLA linkage and recessivityHuman Immunology, 1981
- Genetics of HemochromatosisNew England Journal of Medicine, 1979
- Histocompatibility antigens and haemochromatosis in IrelandIrish Journal of Medical Science, 1979
- Hereditary HemochromatosisNew England Journal of Medicine, 1979
- Serum Ferritin as a Possible Marker of the Hemochromatosis AlleleNew England Journal of Medicine, 1979
- HLA Antigens in Patients with Idiopathic Hemochromatosis (IH)Tissue Antigens, 1978
- Idiopathic HemochromatosisNew England Journal of Medicine, 1977
- Letter: HLA antigens in haemochromatosis.BMJ, 1975
- Surgery and AnesthesiologyScandinavian Journal of Clinical and Laboratory Investigation, 1968
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955