Observations on antigenic variation in a strain ofTrypanosoma bruceigrowing in mice
- 1 March 1964
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 62 (1) , 69-80
- https://doi.org/10.1017/s0022172400039784
Abstract
Variation in agglutinating and protective antigens was studied in a strain ofTrypanosoma bruceigrowing in mice protected with anti-trypanosomal rabbit serum. It was concluded that the agglutinating and protective antigens were the same, and that variation in the antigenic structure of trypanosome populations exposed to antiserum was due to mutation and selection rather than to adaptation. The mutation rate per organism per division cycle required to account for the experimental findings on the mutational hypothesis was found to have a mean value of 10−5.17.Keywords
This publication has 6 references indexed in Scilit:
- Faculty Opinions recommendation of Mutations of Bacteria from Virus Sensitivity to Virus Resistance.Published by H1 Connect ,2010
- The Influence of Antibody on Serological Variation inTrypanosoma BruceiPathogens and Global Health, 1962
- The Statistical Theory of Bacterial Populations Subject to MutationJournal of the Royal Statistical Society Series B: Statistical Methodology, 1952
- MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCEGenetics, 1943
- A Study ofTrypanosoma RhodesienseRelapse Strains in VitroPathogens and Global Health, 1937
- Ueber Rezidive bei experimenteller Trypanosomiasis1)Deutsche Medizinische Wochenschrift (1946), 1914