Osteosclerotic Myeloma with Polyneuropathy

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Abstract
Five [human] cases of histologically verified plasma cell myeloma in sclerotic skeletal foci and polyneuropathy are reported. Thirty similar cases were collected from the literature. They illustrate a special form of plasma cell neoplasia. The characteristic features are osteosclerosis, polyneuropathy resembling polyradiculitis, nearly normal Hb concentration, bone marrow smears and ESR [erythrocyte sedimentation rate], low concentration of M[immune]-protein and absence of Bence-Jones'' proteinuria. Slow progression of the disease is a possible additional feature. Autoimmune mechanisms probably are involved in the pathogenesis. This hypothesis is based on the observation of circulating immune complexes, positive Waaler''s reaction and relative increase in the number of circulating B-lymphocytes.