Improved preservation of endothelial function at 4UC

Publisher Website
Google Scholar
Abstract
Hypothermia combined with chemical cardioplegia is routinely usedclinically for perioperative myocardial protection and for donor heartpreservation. Profound hypothermia can have an adverse influence onpost-preservation endothelial and myocardial functions. In this study, weinvestigated the effect of temperature on endothelial and myocardialfunctions following global cardiac ischaemia in the isolated rat heart. A5-hydroxytryptamine (5-HT)-induced increase in coronary flow was used as aselective probe to assess endothelial function, while myocardial functionwas measured by a working rat heart model. After recording controlobservations for endothelial and myocardial functions, hearts were keptischaemic for 30 or 60 min without cardioplegia (groups 1 and 2,respectively) and for 60, 90 or 120 min following a single infusion of St.Thomas' Hospital solution (groups 3, 4 and 5, respectively). In each group,hearts were kept ischaemic at 20 degrees C or at 4 degrees C (n = 12 ineach group). Endothelial and myocardial functions were reevaluated andcompared with control values.(ABSTRACT TRUNCATED AT 250 WORDS)

This publication has 0 references indexed in Scilit: