The Penicillin-Sensitive Patient

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Abstract
THE efficacy of penicillin therapy for diseases caused by sensitive bacteria is unquestioned. Clinicians turn with confidence to penicillin or one of the semisynthetic derivatives in treating serious infections, recognizing its bactericidal properties, tissue penetrability and lack of toxicity, even at high blood concentrations. The major pitfall in the use of these drugs is the occurrence of allergic reactions — unpredictable in onset, variable in severity, and frequent enough that every physician encounters this problem in his practice.Many efforts have been made to neutralize the cause of penicillin allergy by altering the penicillin molecule. An early theory that the . . .

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