SEASONAL VARIATIONS IN ENDOTOXIN SUSCEPTIBILITY OF RABBITS

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Abstract
Susceptibility of rabbits to endotoxin increased in winter and decreased in summer. The activation of thyroid gland in winter was related to the intense dyspneic response due to epinephrine discharge in this season. However, the characteristic metabolic derangements, such as the depletion of the liver glycogen, especially pronounced in winter, was independent of susceptibility and seemed to be related to the enhanced hepatic metabolism in cold adaptation. Concerning the summer non-susceptibility, besides the lessening of the above potentiating factors, some central alterations in reducing the disturbances in the autonomic nervous system in relation to the activation of the febrile mechanism must be assumed.

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