Pharmacokinetics and Pharmacodynamics of ORG NC 45 in Man
Open Access
- 1 June 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52, 37S-41S
- https://doi.org/10.1093/bja/52.suppl_1.37s
Abstract
A combined pharmacokinetic-pharmacodynamic study of Org NC45 was performed in six patients undergoing elective oro-facial surgery. The pharmacokinetics could be described using a two-compartment open model with a distribution half-life of approximately 4 min and an elimination half-life of approximately 31 min. The pharmacokinetic parameters confirm earlier clinical findings that Org NC 45 has a more rapid onset and a shorter duration of action than pancuronium, and a faster recovery rate. When comparing the pharmacokinetic and pharmacodynamic parameters the biophase could be distinguished from both the central and the peripheral compartments. The mean steady-state plasma concentration producing a 50% block of the twitch response was 0.137 μg ml −1 (range 0.118—0.176 μg ml −1 ).Keywords
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