Influence of Alpha Tocopherol on Implantation in Old Rats.

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Abstract
The implantation rate in [female] rats on a purified, vit. E-deficient diet was compared with that in animals on the same diet supplemented either by single post-mating doses or by continuous addition of [alpha]-tocopherol. Failure of implantation was observed after the 8th mo. in the deficient group. With continuous tocopherol admn., the implantation rate was normal after 1 yr. Single post-mating supplements increased the rate in older rats significantly. Tocopherol seems to be essential for implantation at least in older rats. The requirements increase steeply with age. The changes leading to the failure of implantation can be prevented but, once present, only partly cured by a-tocopherol.