Influenza virus immunization. Antibody response and adverse effects in children with renal disease
- 16 June 1978
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 239 (24) , 2559-2561
- https://doi.org/10.1001/jama.239.24.2559
Abstract
Before and 4 wk after immunization with a single 0.5-ml dose of influenza virus vaccine, sera from 36 children with renal diseases were tested for serum hemagglutinating-inhibiting antibody (HAI) titers to A/New Jersey/76, A/Victoria/75 and A/Port Chalmers/73. Before immunization, 1:40 HAI antibodies to A/New Jersey were noted in 1 child, to A/Victoria in 10 children (27%) and to A/Port Chalmers in 25/34 children (68%). Serum HAI titers increased 4-fold or more (P < .01) in 31/36 children (86%) after immunization. The type of the renal disease and therapy with prednisone had no effect on the rise of serum HAI titers (P > .05). Of the 7 children with preimmunization proteinuria, 4 had a transient rise in protein levels following immunization. None required an increased prednisone dose for exacerbation of nephrotic syndrome. Children with chronic renal problems should be protected against influenza.This publication has 1 reference indexed in Scilit:
- Influenza Vaccination of Patients with Glomerular DiseasesAnnals of Internal Medicine, 1974