Effects of the long-term (7-9 months) feeding of iodine-enriched eggs on lipid metabolism of rats.

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Abstract
The effect of long-term (7-9 mo.) feeding of a diet containing I-enriched eggs, which had considerably higher amounts of I than ordinary eggs, was studied on the lipid metabolism in rats. A laboratory powder chow was added at 1% (wt/wt) level with ordinary egg powder (ordinary egg diet as control: 35.1 .mu.g I/100 g diet) or I-enriched egg powder (I-enriched egg diet: 392.2 .mu.g I/100 g diet). The animals were meal-fed twice a day and allowed to take daily voluntary running exercise in wheels for 24 h. The long-term feeding with I-enriched eggs did not influence body weight gain, food intake, voluntary running activity, weights of several organs and adipose tissues, and lipid concentrations in several organs and tissues. The serum lipid levels were decreased after the feeding of I-enriched eggs. A decrease in triacylglycerol (TG) level was significant (P < 0.05). The long-term feeding with I-enriched eggs resulted in a reduced hepatic-intestinal TG production rate and also an enhanced TG removal rate from blood. Skeletal muscle and adipose tissue lipoprotein lipase activity was significantly elevated with the feeding of I-enriched eggs. The lowering effect of blood TG level with feeding of I-enriched eggs may be mediated by either a reduced hepatic-intestinal TG production or an enhanced peripheral removal of circulating TG. Serum total I concentration was 5 times higher in the I-enriched egg fed rats as compared to controls, but the serum concentrations of TSH and thyroid hormones as well as the thyroid total I content were not different between the 2 dietary groups of animals. No relationship between the hypotriacylglycerolemic effect of I-enriched eggs and the serum levels of thyroid relating hormones was demonstrated.