SERUM DISEASE

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Abstract
After diphtheria antitoxin came into general use in the treatment of diphtheria in 1894, the occurrence of exanthems, joint pains, etc., following the injection began to be reported. Various observers noted a larger or smaller proportion of such reactions among the cases coming under their care, and it was generally agreed that the reactions were a source of annoyance rather than of danger. Gradually there have accumulated reports of cases in which injections of serum have been followed by alarming symptoms, and in very exceptional instances even by death. During the past three years many workers have reported the results of investigations on the effects on animals of injections of alien blood serums. Some of the obscure phenomena associated with the toxic action of horse serum in man are illuminated by these investigations. It was thought that it might be profitable to study the records of serum

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