Difference in Gene Expression Profiles between Human CD4+CD25+ and CD4+CD25− T Cells

1 November 2003

journal article
research article
Published by Wiley in Annals of the New York Academy of Sciences

Vol. 1005 (1) , 279-283
https://doi.org/10.1196/annals.1288.043

Abstract

We studied the gene expression profiles of human CD4+CD25+ and CD4+CD25− T cells by using cDNA microarrays. Our preliminary results indicate that there are likely significant differences in the regulation of apoptosis, cell cycle, cytokine receptor, cell-cell interaction, and stress pathway genes between these two subtypes of T cells.

Keywords

This publication has 8 references indexed in Scilit:

Quantitative quality control in microarray experiments and the application in data filtering, normalization and false positive rate prediction
Bioinformatics, 2003
Three color cDNA microarrays: quantitative assessment through the use of fluorescein-labeled probes
Nucleic Acids Research, 2003
How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach
Genome Biology, 2002
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
Nature Immunology, 2001
Quantitative quality control in microarray image processing and data acquisition
Nucleic Acids Research, 2001
Regulatory T Cells in Autoimmmunity
Annual Review of Immunology, 2000
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
The Journal of Immunology, 1995
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis
Nature, 1990