Statistical Modeling of Pharmacokinetic Systems
- 1 March 1976
- journal article
- Published by ASME International in Journal of Dynamic Systems, Measurement, and Control
- Vol. 98 (1) , 37-43
- https://doi.org/10.1115/1.3426982
Abstract
A statistical treatment of a pharmacokinetic compartmental model is described, wherein the initial drug concentration and/or the rate constants governing the distribution of the drug between the appropriate compartments are considered to be random variables. A specific pharmacokinetic model which describes the profile of the antibiotic coumermycin A, following intravenous and oral administration in man, is stochastized and a numerical comparison between the deterministic and the mean of the random solutions as a function of time is presented.Keywords
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