PHARMACOKINETICS OF TIAPRIDE AND ABSOLUTE BIOAVAILABILITY OF 3 EXTRA-VASCULAR FORMS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 20  (2) , 62-67
Abstract
The pharmacokinetic properties of a single 200-mg dose of tiapride [a neuroleptic] were studied in 8 healthy volunteers (4 males and 4 females). The drug was administered by i.v., i.m. and oral routes (solution and tablets). Plasma and urine concentrations were determined by a high-performance liquid chromatography. The results were compatible with a linear 2-compartment model. The half-life in the disposition phase range from 2.19-4.55 h (mean 3.23 h). Peak plasma concentrations were always reached within 2 h. The percentage of absorption of the i.m. and the 2 oral formulations varied from 49.3-98.9%. The renal clearance varied from 11.8-24.9 l/h. The drug was mainly eliminated in unmetabolized form in the urine (75.6%).

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