Effect of Phospholipase A2 Inhibitor ONO-RS-082 on Substance P-lnduced Histamine Release from Rat Peritoneal Mast Cells
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 97 (3) , 226-228
- https://doi.org/10.1159/000236123
Abstract
Rat peritoneal mast cells purified on a Percoll gradient were challenged with substance P (SP) and the effect of phospholipase A2 inhibitor ONO-RS-082 on SP-induced histamine release from the cells was investigated. 10––5 mol/l SP caused a significant histamine release and the amount of histamine release reached maximum at 1 min after the challenge. ONO-RS-082 inhibited the SP-induced histamine release in a concentration-dependent manner at the concentration from 10––6 to 10––4 mol/l, suggesting possible involvement of phospholipase A2 in SP-induced histamine release from rat peritoneal mast cells.Keywords
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