Fistola doppia del Labbro inferiore in otto Membri della stessa Famiglia

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Abstract
SUMMARY: A relatively rare malformation (double fistula of the lower lip, associated in most cases with cleft lip and palate) has been found to be exceptionally present in eight members (mother and seven children) of the same family.A survey has been made of present knowledge on the genesis of this malformation, and a genetical interpretation of the observation has been tentatively suggested.Different data collected on the problem point, in the author's opinion, to an hypothesis which should admit the occurrence of a chromosomal mutation, associated with fusion of the couple of maternal chromosomes, as the most acceptable one.Exogenous factors, such as, in particular, deficiency factors, could have played a predisposing or facilitating role.

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