Prevalence of Type-C Particles in Visceral Tissues of Embryonic and Newborn Mice2

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Abstract
Immature budding type-C particles were demonstrated in 59% of the visceral tissues from 72 of 85 embryonic and newborn mice of all strains examined; thus 85% of the embryonic or newborn mice tested had 1 or more positive tissues. Muscle tissue was uniformly negative. The data offer supportive evidence for the transmission of subinfectious virus information from parent to offspring as part of the genetic makeup of normal cells as proposed in the viral oncogene hypothesis. This hypothesis was based in part on the demonstration of expressions of the major polypeptide (group-specific-1) of the type-C RNA tumor viruses in visceral tissue of mouse embryos.

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