Carcinogenesis by a single dose ofN‐methyl‐N‐formylhydrazine

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Abstract
Single s.c. injections of N-methyl-N-formylhydrazine were given to randomly bred Swiss mice. The females received 180 .mu.g/g body wt, while 2 groups of males were treated with either 120-100 .mu.g/g body wt. The treatment resulted in induction of tumors of lungs with an incidence of 40% in the females. In males treated with the higher and lower doses, the incidences of preputial gland tumors were 12 and 12%, respectively. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of lungs, squamous cell papillomas, and carcinomas of preputial glands. N-Methyl-N-formylhydrazine is a constituent of the edible wild false morel mushroom Gyromitra esculenta, to which the human population is exposed in measurable quantities, sometimes at a single meal.