Oligonucleotides Containing Acyclic Nucleoside Analogues with Carbamate Internucleoside Linkages

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Abstract
Synthesis of 2′-deoxy-2′,3′-secothymidine t and its dimer t∗t, where the two 2′-deoxy-2′,3′-secothymidine t units are connected via a carbamate, ∗=3′-NH-CO-O-5′, internucleoside linkage has been achieved. These building blocks were protected in the 5′-position, converted into their phosphoramidites, or attached onto CPG, and then used for “chimeric oligonucleotide” synthesis.