The Effect of -9-Tetrahydrocannabinol on Herpes Simplex Virus Replication

1 August 1980

journal article
research article
Published by Microbiology Society in Journal of General Virology

Vol. 49 (2) , 427-431
https://doi.org/10.1099/0022-1317-49-2-427

Abstract

Herpes simplex virus type 1 (HSV-1) and HSV-2 failed in an identical fashion to replicate and produce extensive c.p.e. [cytopathic effects] in human cell monolayer cultures exposed (8 h before infection, at infection or 8 h post-infection) to various concentrations of .DELTA.-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent African green monkey cells. Possible mechanisms for this antiviral activity are discussed.