IMMUNOGENICITY AND PROTECTIVE EFFICACY IN A RHESUS-MONKEY MODEL OF VACCINE AC NFU1(S-) MRC AGAINST PRIMARY TYPE-2 HERPES-SIMPLEX VIRUS-INFECTION
- 1 January 1982
- journal article
- research article
- Vol. 63 (4) , 378-387
Abstract
Adult and juvenile Rhesus monkeys were vaccinated with subunit formaldehyde-inactivated vaccine Ac NFU1(S) MRC; no local or systemic side-effects followed vaccination. Vaccinated monkeys developed neutralizing and immunoprecipitating antibody to both type 1 and 2 herpes simplex virus. Antibody levels declined with time but were re-stimulated after virus challenge and to a lesser extent after attempted virus reactivation. There was evidence of protection against s.c. challenge with live type 2 herpes simplex virus.This publication has 20 references indexed in Scilit:
- Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine.British Journal of Ophthalmology, 1981
- Prepubertal vaccination of mice against experimental infection of the genital tract with type 2 herpes simplex virusArchiv für die gesamte Virusforschung, 1980
- Preparation and efficacy of an inactivated subunit vaccine (NFUI BHK) against type 2Herpes simplex virus infectionMedical Microbiology and Immunology, 1978
- Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNACell, 1978
- Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology; evidence towards pre-pubertal vaccination of sero-negative female subjectsArchiv für die gesamte Virusforschung, 1977
- Effect of Immunization on Acute and Latent Infections of Vaginouterine Tissue with Herpes Simplex Virus Types 1 and 2The Journal of Infectious Diseases, 1977
- Experimental Human Reinfection with Herpes Simplex VirusJournal of Investigative Dermatology, 1973
- The Role of Type Specific and Cross Reacting Structural Antigens in the Neutralization of Herpes Simplex Virus Types 1 and 2Journal of General Virology, 1973
- Polyoma transformation of hamster cell clones—an investigation of genetic factors affecting cell competenceVirology, 1962
- Reactions of Autoinoculation for Recurrent Herpes SimplexArchives of Dermatology, 1961