Alteration of Erythrocyte Lipid Composition following Total Parenteral Nutrition in the Rat
- 1 January 1989
- journal article
- research article
- Published by Wiley in Journal of Parenteral and Enteral Nutrition
- Vol. 13 (1) , 47-50
- https://doi.org/10.1177/014860718901300147
Abstract
Rats were infused continuously for 7 days with a complete total parenteral nutrition (TPN) solution in which 27.5% total calories were given as a parenteral lipid emulsion containing soybean oil (Liposyn) or safflower oil (Intralipid) emulsified with egg phospholipid (PL). Compared to sham-operated rats fed chow, the erythrocyte membranes from rats given TPN with lipid emulsion had increased cholesterol and PL but normal molar cholesterol:PL ratios. The fatty acid changes in sphingomyelin and phosphatidylcholine, in particular, suggested replacement of endogenous PL with the exogenous egg PL infused with the emulsion. The changes in membrane lipid composition were accompanied by greater resistance of the cells from rats given TPN to osmotic lysis in vitro.Keywords
This publication has 34 references indexed in Scilit:
- Modulation of human erythrocyte shape and fatty acids by dietBiochimica et Biophysica Acta (BBA) - Biomembranes, 1986
- Effect of Intralipid-infusion on erythrocyte membrane in rabbitsBiochemical Medicine, 1983
- Erythrocyte membrane in rats fed high erucic acid-containing mustard oil: Osmotic fragility, lipid composition, and (Na+, K+)- and (Ca2+, Mg2+)-ATPasesBiochemical Medicine, 1983
- Abnormalities in erythrocyte membrane phospholipids in patients with liver cirrhosisBiochemical Medicine, 1982
- Intravascular metabolism of an artificial transporter of triacylglycerols alterations of serum lipoproteins resulting from total parenteral nutrition with intralipidBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
- INTRALIPID INDUCED HAEMOLYSISBritish Journal of Haematology, 1982
- Appearance and Characterization of Lipoprotein X during Continuous Intralipid Infusions in the NeonateJournal of Clinical Investigation, 1979
- Incorporation of phosphatide precursors from serum into erythrocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
- Metabolism of red-cell lipidsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
- Metabolism of red-cell lipids I. Incorporation in vitro of fatty acids into phospholipids from mature erythrocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965