Effect of Furosemide on Serum Clearance and Renal Excretion of Digoxin

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Abstract
Serum turnover and urinary excretion of digoxin with or without oral furosemide were studied in 6 healthy subjects who received 0.006 mg/kg body wt digoxin i.v. During furosemide treatment, the total amount of urinary digoxin did not change but the digoxin clearance during the diuretic phase and the digoxin excretion after the diuresis decreased significantly. The average serum half-life was prolonged from 37 h in the control period to 86 h in the furosemide period. Decreased glomerular filtration rate by volume depletion might have been responsible for the decreased excretion of digoxin, but there was no significant difference in urine volume after diuresis between the 2 periods, suggesting the possibility of inhibition of tubular secretion of digoxin by furosemide. Serum digoxin concentrations may be elevated if furosemide were given more frequently.

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