The Influence of Phenformin on Blood Lactic Acid in Normal and Diabetic Subjects During Exercise

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Abstract
In 4 normal and 7 diabetic subjects, the variations of blood sugar, total CO2 and blood lactic acid were investigated during muscular work (300 and 600 kg meter/minute) before and during treatment with phenformin in a dosage of 75 mg/day for at least 1 week. In both diabetics and nondiabetics phenformin did not aggravate the normal increase in blood lactic acid during muscular work. In the steady state of work the levels of blood lactic acid in relation to pulse rates were within normal limits. Small reductions of blood sugar and total CO2 during work were demonstrated in diabetics treated or not treated with phenformin.