Comparison of 3, 5 and 7 days' treatment with Quinimax for falciparum malaria in Guinea-Bissau.

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Abstract
For treatment of malaria, the World Health Organization recommends 10 mg of quinine per kg bodyweight 3 times a day for at least 7 d. In Guinea-Bissau, as in several other African countries, a 3 d treatment regimen (10 mg/kg twice daily) is currently used. We therefore compared the 3 d treatment period with periods of 5 and 7 d. A total of 145 children with clinical malaria due to monoinfection with Plasmodium falciparum, with ≥20 parasites per 200 leucocytes, were treated with intramuscular Quinima TM 10 mg per kg body-weight twice daily for 3, 5 or 7 d.The children were then examined once weekly for 4 weeks. Following the 3 d treatment regimen, 34 of 43 children (79%) had parasitaemia on day 28 or before; following the 5 d treatment regimen, 36 of 40 children (90%) did so; and following the 7 d treatment regimen, 7 of 62 children (11%) were parasitaemic at that time. This study thus suggests that the currently recommended 3 d QuinimaxTM treatment regimen in Guinea-Bissau for moderate and severe malaria is not effective.