On the mechanism of drug‐induced gingival hyperplasia
- 1 May 1991
- journal article
- review article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 20 (5) , 201-209
- https://doi.org/10.1111/j.1600-0714.1991.tb00419.x
Abstract
Proposed mechanisms of the side effect of drug-induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans, immunoglobulins, gingival fibroblast phenotype population differences, epithelial growth factor, pharmacokinetics and tissuebinding, collagenase activation, disruption of fibroblast cellular sodium/calcium flux, folic acid and a combination hypothesis are evaluated.Keywords
This publication has 85 references indexed in Scilit:
- Characterization of a Specific Antiserum to Rabbit Stromelysin and Demonstration of the Synthesis of Collagenase and Stromelysin by Stimulated Rabbit Articular ChondrocytesCollagen and Related Research, 1986
- The effects of platelet‐derived transforming growth factor β on normal human diploid gingival fibroblastsEuropean Journal of Biochemistry, 1986
- Trypsin activation. Effect of the Ile-Val dipeptide concentration on Kazal inhibitor binding to bovine trypsinogenBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1985
- Activating effect of the Ile-Val dipeptide on the catalytic properties of bovine trypsinogenBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1985
- Phenytoin modulates connective tissue metabolism and cell proliferation in human skin fibroblast culturesArchives of Dermatology, 1985
- The effects of chlorhexidine and mechanical methods of plaque control on the recurrence of gingival hyperplasia in young patients taking phenytoinBritish Dental Journal, 1982
- Gingival hyperplasia and folic acid deficiency from anticonvulsive drug therapy A theoretical relationshipJournal of Theoretical Biology, 1977
- Levels of 5,5-Diphenylhydantoin and its Major Metabolite in Human Serum, Saliva, and Hyperplastic GingivaJournal of Dental Research, 1974
- Speculations Regarding the Nature of Gingival Hyperplasia Due to Diphenylhydantoin‐sodium.Acta Medica Scandinavica, 1955
- VITAMIN C IN EPILEPSYThe Lancet Healthy Longevity, 1940