Effects of Frusemide in Chronic Renal Failure

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Abstract
The present experiment studied whether the use of high dose frusemide in chronic renal failure will increase the glomerular filtration rate (GFR). Seven patients in stable chronic renal failure were admitted to hospital for 20 days. For 10 days fluid balance was maintained and no diuretics given. During the next 10 days, 1 g frusemide was given orally, with fluid and electrolyte replacement based on the 24-h urine collections which were made throughout the 20-day period. Daily estimations of Na, K, urea, creatinine and osmolality were made on plasma and urine. The excretion of water (P < 0.01), Na (P < 0.01) and K (P < 0.05) increased significantly during the treatment period. There was no significant change in blood pressure, weight, creatinine clearance (C/CR), clearance of urea (C/urea), total urea and creatinine excretion, serum Na, K or osmolality. One gram of frusemide, administered to patients in stable chronic renal failure, does not have any effect on intrinsic renal function. There was a significant increase in urine volume, as well as Na and K excretion.

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