ACTION OF STRYCHNINE TO CORTICAL NEURONS

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Abstract
The effect of topically applied strychnine was studied on pyramidal- and non-pyramidal tract neurons in cats'' cerebral motor cortex by means of a micro-electrode technique under barbiturate anesthesia. In spontaneous activities of the neuron, the most common intracellular potential changes are a progressive increase of depolarizing waves EPSPs leading to the formation of long-lasting depolarizing waves summated EPSPs and an increase and then a decrease of hyperpolarizing waves EPSPs through an advancing course of strychninization. Single shocks to the medullary pyramid elicited almost the same changes the responses of the neurons during strych-ninization. The action of strychnine is that it facilitates the excitatory and inhibitory synaptic transmission and that the excitatory synaptic transmission remains active after the inhibitory one has been blocked.