Comparative Trial of Single‐Dose Versus Twice‐Daily Sisomicin in Bacteriuric Patients

Publisher Website
Google Scholar
Abstract
Sisomicin was administered as a single daily i.m. injection (160 mg) or as 2 daily injections (80 mg) to 50 patients with bacteriuria superimposed on chronic urologic diseases in a randomized controlled fashion. The administration of 2 daily doses was significantly more effective (P < 0.01) in achieving cure than the injection of a single daily dose. The renal function, as expressed by creatinine clearance, became impaired significantly more often (P < 0.05) in the patients receiving the single daily dose of sisomicin.