Application of Fast LC to Pharmaceutical Analysis: Dopamine * HCI
- 1 November 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 25 (11) , 494-500
- https://doi.org/10.1093/chromsci/25.11.494
Abstract
A reversed-phase HPLC method for the determination of the dopamine hydrochloride content of pharmaceutical intravenous solutions is developed using short (3-cm) columns packed with 3-µm particles. Total analysis time for the stability indicating assay, which is capable of separating the analyte from all its common degradates and formulation matrix components, is 2 min. The assay is equivalent in performance (accuracy, precision, separation behavior, ruggedness) to a standard method recommended by the United States Pharmacopeia (USP). Common components of conventional HPLC systems are evaluated with respect to their utility for this application of fast LC.This publication has 2 references indexed in Scilit:
- Electrochemical study of the oxidation of .alpha.-methyldopamine, .alpha.-methylnoradrenaline, and dopamineThe Journal of Organic Chemistry, 1983
- Rapid Analysis of Some Commonly Abused Drugs by LCJournal of Chromatographic Science, 1982