Concentration‐response curves for ethylene‐oxide‐induced heritable translocations and dominant lethal mutations

1 January 1990

journal article
research article
Published by Wiley in Environmental and Molecular Mutagenesis

Vol. 16 (2) , 126-131
https://doi.org/10.1002/em.2850160209

Abstract

Male mice were subjected to repeated inhalation exposures to different concentrations (165, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5‐week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable translocations. The concentration‐response curves for both endpoints are not linear but are markedly concave upward. Significant increases in dominant lethals were detected at all concentrations, except the lowest one. In comparison, the incidences of heritable translocations were significantly increased at all concentrations.

Keywords

This publication has 22 references indexed in Scilit:

A Balanced Translocation in Mice with a Neurological Defect
Science, 1986
Dominant lethal effects of acrylamide in male mice
Mutation Research Letters, 1986
Increased dominant-lethal effects due to prolonged exposure of mice to inhaled ethylene oxide
Mutation Research Letters, 1983
Screening strategy for chemicals that are potential germ-cell mutagens in mammals
Mutation Research/Reviews in Genetic Toxicology, 1983
Comparison of two methods for detecting translocation heterozygotes in mice
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1981
Evidence that chromosome rearrangements occur after fertilization following postmeiotic treatment of male-mice germ cells with EMS
Mutation Research Letters, 1981
Heritable translocation and dominant-lethal mutation induction with ethylene oxide in mice
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
The mutagenic potential of ethylene oxide using the dominant-lethal assay in rats
Toxicology and Applied Pharmacology, 1977
Evidence that Linkage Group IV as well as Linkage Group X of the mouse are in chromosome 10
Genetics Research, 1975
Strain and sex variations in the sensitivity of mice to dominant-lethal induction with ethyl methanesulfonate
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1969