Zanhasaponins A and B, Antiphospholipase A2Saponins from an Antiinflammatory Extract ofZanha africanaRoot Bark
- 1 November 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (11) , 1158-1160
- https://doi.org/10.1021/np970221r
Abstract
A MeOH extract from Z. africana was examined for topical antiinflammatory activity and proved to be active against arachidonic acid (AA) acute edema, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced chronic inflammation, and oxazolone delayed-type hypersensitivity in mice. The extract also showed significant inhibitory activity of Naja naja phospholipase A2 when a polarographic method was used. Two oleanane-type triterpene saponins, zanhasaponins A (1) and B (2), and the cyclitol pinitol (4), isolated from the extract, were active as inhibitors of PLA2. A further saponin, zanhasaponin C (3) was inactive in this assay.Keywords
This publication has 7 references indexed in Scilit:
- Assay method for myeloperoxidase in human polymorphonuclear leukocytesPublished by Elsevier ,2004
- Two Fungal Lanostane Derivatives as Phospholipase A2 InhibitorsJournal of Natural Products, 1996
- Screening of tropical medicinal plants for antiinflammatory activityPhytotherapy Research, 1995
- Regulation of Extracellular Phospholipase A2Activity: Implications for Inflammatory DiseasesDNA and Cell Biology, 1992
- Structure De L'Acide Zanhagenique, Triterpenoide Nouveau Isole De Zanha AfricanaBulletin des Sociétés Chimiques Belges, 1992
- Structure de la Zanhine et de la Medicagine, Deux Prosapogenines Nouvelles Isolées de Zanha Golungensis HiernBulletin des Sociétés Chimiques Belges, 1987
- Structure de L'Acide Zanhique et de L'Acide Zanhique‐γ‐Lactone, Triterpenoïdes Nouveaux Isoles de Zanha Golugensis et de Ganophyllum GiganteumBulletin des Sociétés Chimiques Belges, 1984