The EGF-TM7 family: unusual structures at the leukocyte surface

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Abstract
The isolation of cDNA clones encoding mouse F4/80, human epidermal growth factor (EGF) module‐containing mucin‐like hormone receptor 1 (EMR1) and human CD97 has resulted in the description of a novel family of seven‐transmembrane spanning cell surface molecules. These members of the EGF‐TM7 family are characterized by a variable number of NH2‐terminal EGF domains and seven transmembrane‐spanning hydrophobic regions, which demonstrate a degree of sequence homology to the corresponding region in members of the G‐protein‐coupled peptide hormone receptor family. The F4/80 molecule is macrophage‐restricted, as determined by immunohistochemical analysis of a wide range mouse tissues, while mRNA transcripts encoding EMR1, the predicted human F4/80 homologue, also appear to be abundantly expressed by cells of the myelomonocytic lineage. CD97, for which a cellular ligand has been identified (CD55), is expressed on a diverse array of leukocytes and is markedly upregulated on activated T and B cells. The regulation of expression of the EGF‐TM7 genes, the physiologic function(s) of these novel receptors and the further identification of their ligands is the subject of both intense study and this review. J. Leukoc. Biol. 63: 271–280; 1998.

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