Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses.

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Abstract
A monoclonal antibody specific for the hemagglutinin (HA) of influenza A X-31 (H3N2) virus (X-31) was obtained during a fusion of spleen cells from a BALB/c mouse immunized with influenza A/PR/8/34 (H1N1) virus (PR8). This monoclonal antibody (Py206) shares crossreactive idiotopes expressed on several monoclonal antibodies specific for PR8 HA and X-31 HA as well as an individual idiotope shared with one monoclonal antibody specific for X-31 HA. The presence of shared idiotypy among antibodies of such diverse binding specificities may result from regulation by idiotype-specific T cells. In addition, the results suggest that, in contrast to the diversity of paratypes expressed, relatively few germ-line variable region genes may be used in the antibody response to influenza A virus antigens.

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