Genetic mapping by single sperm typing
- 24 April 2009
- journal article
- review article
- Published by Wiley in Animal Genetics
- Vol. 22 (2) , 105-115
- https://doi.org/10.1111/j.1365-2052.1991.tb00652.x
Abstract
The polymerase chain reaction makes it possible to analyse DNA sequences in a single cell and has led to a new approach for constructing genetic maps. We describe a procedure called 'sperm typing' which can accurately classify individual meiotic products as recombinant of non-recombinant. This permits the linkage relationships among DNA polymorphisms to be determined without pedigree analysis.Keywords
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