Mutator Genes Giving Rise to Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa
Open Access
- 1 October 2008
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (10) , 3810-3813
- https://doi.org/10.1128/aac.00233-08
Abstract
Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL , as well as mutators that have not yet been described for P. aeruginosa , including PA3958 and RadA (PA4609).Keywords
This publication has 21 references indexed in Scilit:
- Proteomic, Microarray, and Signature-Tagged Mutagenesis Analyses of AnaerobicPseudomonas aeruginosaat pH 6.5, Likely Representing Chronic, Late-Stage Cystic Fibrosis Airway ConditionsJournal of Bacteriology, 2008
- Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substancesNature Protocols, 2008
- Hypermutability in environmental Pseudomonas aeruginosa and in populations causing pulmonary infection in individuals with cystic fibrosisMicrobiology, 2007
- Biological cost of hypermutation in Pseudomonas aeruginosa strains from patients with cystic fibrosisMicrobiology, 2007
- Comprehensive transposon mutant library of Pseudomonas aeruginosaProceedings of the National Academy of Sciences, 2003
- Importance of Uracil DNA Glycosylase in Pseudomonas aeruginosa and Mycobacterium smegmatis, G+C-rich Bacteria, in Mutation Prevention, Tolerance to Acidified Nitrite, and Endurance in Mouse MacrophagesJournal of Biological Chemistry, 2003
- Interactions among the Escherichia coli mutT, mutM, and mutY damage prevention pathwaysDNA Repair, 2003
- Characterization of the GO system ofPseudomonas aeruginosaFEMS Microbiology Letters, 2002
- The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutantsMolecular Microbiology, 2002
- High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung InfectionScience, 2000