The Role of Complement and Its Receptor in the Elimination of Immune Complexes
- 21 August 1986
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 315 (8) , 488-495
- https://doi.org/10.1056/nejm198608213150805
Abstract
Information that has accumulated in the past several years has necessitated a radical reexamination of the role of complement in immune-complex disease. The starting point was the recognition in the mid-1970s of an association between a genetic deficiency of complement components and susceptibility to immune-complex disease. More recent work has established that complement itself, by binding to the antigen–antibody complex, can greatly modify the structure and biologic activity of the complex. In addition, the structure and properties of the receptor for the activated third component of complement have been characterized. These new data have led to a reappraisal of the . . .Keywords
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