Evidence for an Adrenergic Component in the Nervous Mechanism of Sweating in Man.

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Abstract
Following the admn. of Dibenamine (N,N-dibenzyl-beta-chloroethylamine hydrochloride), a new highly specific adrenergic-blocking drug, it was found that spontaneous palmar sweating in man was inhibited. Intraven. injn. of neosynephrine induced moderate sweating. After Dibenamine, neosynephrine remained without effect on the sweat function. Mecholyl given subcut. after Dibenamine induced profuse sweating, mostly on the face and on the dorsum of the hands. From the preliminary data presented in this paper it appears that, in addition to the known cholinergic fibers supplying the sweat glands, there is also an adrenergic component in the nervous mechanism in man.

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