Note on the Chemistry of Dramamine
- 3 June 1949
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 109 (2840) , 574
- https://doi.org/10.1126/science.109.2840.574
Abstract
Attempts to eliminate undesireable depressive side effects of antihistamine drugs by combining them with central nervous system stimulating xanthines have usually failed due to low ioni-zation of xanthines. Dramamine (beta-dimethylaminoethyl ben-zohydryl ether 8- chlorotheophyllinate) represents a solution of this problem since 8-chlorotheophylline has a sufficiently high ionization to form a stable salt.Keywords
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