ACTIVITY OF DESOXYCORTICOSTERONE ACETATE IN PROPYLENE GLYCOL BY ORAL AND INTRAVENOUS ROUTES IN ADRENALECTOMIZED DOGS, AND ITS EFFECT ON THE CARDIAC ARHYTHMIA OF ADRENAL INSUFFICIENCY

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Abstract
Desoxycorticosterone acetate (DCA) dissolved in propylene glycol, administered orally, did not effectively maintain adrenalectomized dogs. Evidence that some absorption of the active material took place was suggested by the failure of severe adrenal insufficiency to develop before the end of 10 days'' treatment. DCA administered to 3 dogs in severe adrenal insufficiency restored 2. In these 2, the intraven. adm. of DCA in propylene glycol was followed by restoration of normal cardiac rhythm and by improvement in the general condition of the animals within about 3 hrs. The opinion formerly advanced that DCA lacks some factor necessary for cardiac metabolism is not substantiated by these later expts.

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