Preparation and characterization of microencapsulated gelospheres for controlled oral theophylline delivery
- 1 January 2000
- journal article
- Published by Taylor & Francis in Journal of Microencapsulation
- Vol. 17 (6) , 767-775
- https://doi.org/10.1080/02652040050161756
Abstract
Microencapsulated gelospheres were prepared using the water swellable polymers, poly(vinyl alcohol) and polyacrylamide in which the drug was embedded. Polymeric coating was formed by interfacial polymerization using 1,6 hexamine and sebacoyl chloride. The size, shape, in vitro release, kinetics and in vivo efficiency of the formulation were determined. The shape was found to be spherical with a size range below 100 microm. The per cent drug loaded was found to be higher in the case of gelospheres prepared with polyacrylamide than those prepared with poly(vinyl alcohol). The release rate was found to be near zero order. The AUC was found to be higher in the case of polyacrylamide and polyvinyl alcohol gelospheres as compared to plain drug solution.Keywords
This publication has 11 references indexed in Scilit:
- Release rate profiles of theophylline and insulin from stable multiple w/o/w emulsionsJournal of Controlled Release, 1997
- Development of sustained release theophylline pellets coated with calcium pectinateJournal of Controlled Release, 1997
- In vitro dissolution of some commercially available sustained-release theophylline preparationsInternational Journal of Pharmaceutics, 1988
- A simple equation for description of solute release II. Fickian and anomalous release from swellable devicesJournal of Controlled Release, 1987
- A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discsJournal of Controlled Release, 1987
- Mechanisms of solute release from porous hydrophilic polymersInternational Journal of Pharmaceutics, 1983
- Drug Release from Wax Matrices IJournal of Pharmaceutical Sciences, 1968
- Release rates of solid drug mixtures dispersed in inert matrices I Noninteracting drug mixturesJournal of Pharmaceutical Sciences, 1967
- Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices IIIJournal of Pharmaceutical Sciences, 1966
- Interfacial polycondensation. II. Fundamentals of polymer formation at liquid interfacesJournal of Polymer Science, 1959