SYMPATHETICO-ADRENAL DISCHARGES IN HYPOPHYSECTOMIZED RATS

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Abstract
The observations that the hyperglycemic reaction following injn. of adrenalin is reduced after hypophysectomy were studied in rats, with emphasis on the time factors involved and extended to conditions in which adrenalin was not injected but was secreted under the influence of anoxia. The hyperglycemic response to adrenalin secreted under conditions of anoxia, or to its injn. is present for several days after hypophysectomy. This indicates that the hypophysis plays no direct role in sympathecto-adrenal reactions. However, this effect disappears in the course of several wks. following hypophysectomy although the fasting blood sugar level is not significantly altered. This failure of adrenalin to cause hyperglycemia is not explainable on the basis of the regressive changes in thyroid and adrenal cortex nor is it due to alterations in absorption since it is observed under conditions of anoxia when adrenalin is secreted into the blood stream as well as after intraperit. injn. of adrenalin.

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