Cholinesterase inhibition in vitro by OO-diethyl O-p-nitrophenyl thiophosphate (Parathion, E 605)

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Abstract
The in vitro cholinesterase inhibition of a series of samples of parathion and of similar compounds was studied using a rat-brain homogenate as a source of specific cholinesterase. The S-ethyl and S-phenyl isomers of parathion and the oxygen analog of parathion had a powerful inhibitory action. The variable inhibition produced by samples of parathion was entirely ascribed to contamination with the S-ethyl isomer of parathion. A highly purified sample, containing only a trace of this isomer, had a very low inhibitory action.