Ingestion of Latex Particles by Chicken Fibroblasts in Tissue Culture.

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Abstract
Ingestion of polystyrene latex (PSL) particles measuring 0.264 [um] in diameter has been demonstrated in chicken fibroblasts in vitro. PSL was added to cultures of chicken fibroblasts grown on carbon-collodion coated steel grids and these mounts removed at intervals of 1/2 to 24 hours. The fixed and metal shadowed whole cell preparations revealed PSL in various stages of entry into these cells. PSL was found in invaginations of the cell wall and in vacuoles in the cytoplasm. Sections of cultured fibroblasts inoculated with PSL revealed PSL particles in cell vacuoles. The rate of particle uptake, however, was too low to be measured by the method used.

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