Synthesis of Methotrexate Polyglutamates by Bone Marrow Cells from Patients with Leukemia and Lymphoma

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Abstract
Bone marrow cells from children with lymphoblastic leukemia, myeloblastic leukemia and non-Hodgkin's lyrnphorna wcre incubated with tritium-labelled methotrexate in short-term cultures. Cells obtained both during disease activity as weil as during remission synthesized large quantities of methotrexate polyglutamatcs. Synthesis was time- and dose-dependent and occurred with concentrations of methotrexate regularly achicved during conventional treatment with this drug.