REDUCTION OF METHYLMERCURY CONCENTRATION IN NEONATAL RAT BRAINS AFTER ADMINISTRATION OF DIMERCAPTOSUCCINIC ACID TO DAMS WHILE PREGNANT
- 1 January 1978
- journal article
- research article
- Vol. 22 (2) , 357-363
Abstract
Sprague-Dawley rats were gavaged on day 7 of gestation with 1.62, 3.23 or 10 mg methylmercury/kg. Beginning 1 day later, the dams were administered 0, 20 or 40 mg 2,3-dimercaptosuccinic acid(DMSA)/kg per day until they delivered their pups. Concentrations of methylmercury in the brains of pups whose dams were treated with 20 mg DMSA/kg per day were reduced 50% compared with control pups; 40 mg DMSA/kg per day decreased brain concentrations 70% compared to non-chelated controls. DMSA might be effective in protecting the developing organism against morphological and/or behavioral teratological consequences of methylmercury poisoning in utero.This publication has 3 references indexed in Scilit:
- Methylmercury movements across the perfused guinea pig placenta in late gestationToxicology and Applied Pharmacology, 1977
- Time dependent effects produced in chicks after prenatal injection of methylmercuryPharmacology Biochemistry and Behavior, 1976
- Postnatal behavioral effects in mice after prenatal exposure to methylmercuryPharmacology Biochemistry and Behavior, 1976