Conjugate addition of lithium phenylthio- and cyano-[2-(4-chlorobut-1-enyl)]cuprate to cyclic enones. An efficient methylenecyclopentane annulation process
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 935-936
- https://doi.org/10.1039/c39830000935
Abstract
Reaction of the cyclic enones (6)–(11) with the structurally interesting cuprate reagent (2) and (3) provides very good yields of the conjugate addition products (12)–(17); treatment of the latter substancesh with potassium hydride in tetrahydrofuran affords the methylenecyclopentane annulation products (18)–(23), respectively.Keywords
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