13C nuclear magnetic resonance and reactivity of 4H-3,1-benzoxazin-4-ones
- 1 March 1988
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 66 (3) , 416-419
- https://doi.org/10.1139/v88-073
Abstract
Complete carbon-13 nuclear magnetic resonance assignments have been made for 22 4H-3,1-benzoxazin-4-ones. These compounds are alternate substrate inhibitors of human leukocyte elastase, a serine protease involved in tissue degradation. Correlations between the carbon chemical shifts and rates of alkaline hydrolysis are consistent with hydrolysis via attack at C4, and are also useful in the selection of parameters for structure-activity analysis.Keywords
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